NSAIDs in cardiovascular diseases

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NSAIDs in cardiovascular disease: risks and clinical implications Non-steroidal anti-inflammatory Drugs (NSAIDs) are among the most commonly used drugs worldwide and are mainly used for the treatment of pain, inflammation and fever. Despite their wide distribution and OTC availability (over‑the‑counter) you are associated with a number of side effects, particularly in patients with existing cardiovascular disease (CVD). Pharmacological mechanisms of action and cardiovascular effects The effect of the NSAIDs is based on the inhibition of the Cyclooxygenase enzymes (COX‑1 and COX‑2), for the synthesis of prostaglandins responsible. Prostaglandins play an important role in the Regulation of vascular tone, platelet aggregation and Renal blood flow. The selective or non-selective inhibition of these enzymes can trigger the following cardiovascular effects: Increase in blood pressure through a reduction in vasodilator of prostaglandins and decreased renal function. Fluid retention: due to changes in renal perfusion and increased sodium retention. Thromboembolic events: in particular, in the case of selective COX‑2 inhibitors, which affect platelet function less, but the production of prostacyclin (PGI₂) in the vessel to inhibit walls. Epidemiological Evidence Several large observational studies and meta-analyses have shown that the intake is associated with the NSAIDs with an increased risk for cardiovascular events. In particular: an increased risk for myocardial infarction (MI), a higher incidence of stroke, an increase of congestive heart failure exacerbations, a possible risk for arrhythmic events. The risk seems to be dose and duration of intake and the specific NSAIDs to hang out. For example, it was described for Diclofenac significantly higher cardiovascular risk than for Naproxen. Risk groups Particularly patients with risk: of existing coronary heart disease (CHD), arterial hypertension, Diabetes mellitus, chronic renal failure Congestive heart failure. Also, elderly patients are exposed to due to Comorbidities and altered pharmacokinetics with an increased risk. Clinical Recommendations Before the regulation of NSAIDs, a careful Benefit-risk assessment should be performed, especially in patients with CVD or elevated cardiovascular risk profile. Recommendations include: The lowest effective dose for the shortest possible duration. Waiver of COX‑2‑selective inhibitors in patients with hollow cardiovascular risk. Preference for Naproxen in some cases, because it has a more favourable cardiovascular profile (but with an increased gastrointestinal risk). Regular monitoring of blood pressure, of renal function, and of Edema during therapy. Educating the patients about the symptoms of cardiovascular complications (e.g., chest pain, shortness of breath, sudden swelling). Conclusion NSAIDs can cause in patients with cardiovascular disease to significant cardiovascular side effects. An individual risk assessment in a differentiated Medicines selection and close Monitoring are crucial to ensure the safety of these drugs in clinical practice. Further research is needed to understand the long-term effects of various NSAIDs on the cardiovascular System.

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Ang mga modernong gamot sa pag-imprenta ay hinahati sa 10 iba't ibang grupo ayon sa kanilang mekanismo ng pagkilos. Pagkatapos suriin ng doktor ang mga reklamo ng pasyente at ang resulta ng mga pagsusuri, nagrereseta siya ng isa o higit pang gamot, na hindi dapat baguhin nang mag-isa. Ang mga gamot sa puso at daluyan ng dugo ay hindi kabilang sa mga puwedeng irekomenda sa kaibigan. Ang maling desisyon ay maaaring magdulot ng malungkot na kahihinatnan. Lahat ng gamot na pampababa ng presyon ng dugo ay kailangan ng reseta. Sa artikulong ito, tinitingnan natin ang kanilang modernong klasipikasyon base sa mga aktibong sangkap at sa paraan ng epekto nito sa katawan.
NSAIDs in cardiovascular diseases

Kasabay nito, hindi inirerekomenda ang pangmatagalang pag-inom ng mga gamot mula sa kategoryang Diuretics, dahil ang mahahalagang sangkap tulad ng Potassium, Calcium, Magnesium ay mabilis na nailalabas sa katawan kasama ng sobrang tubig at asin. Alinsunod sa katangiang ito, sinasabayan ng mga Diuretics ang pag-inom ng mga gamot na may laman ng mga sangkap na ito. Maaaring ito ay mga vitamin at mineral na complexes, monokomponent, o mga suplemento sa pagkain na may napatunayang klinikal na bisa.

Blood pressure tablets: help or challenge? High blood pressure, known medically as hypertension referred to, relates in Germany millions of people. According to estimates, about 25% of adults suffer from this risk factor for heart attacks, strokes and kidney damage can trigger. An important pillar of the treatment of tablets, the lower the blood pressure. But what is behind these drugs and why is it some people so hard, you regularly take? What is the effect of these tablets actually work? There are different groups of active substances, used in high blood pressure for use: ACE inhibitors (eg, Enalapril): they block a substance that increases blood pressure. Beta-blockers (e.g., Metoprolol): you can slow down the heartbeat and lower the pressure. Calcium channel blockers (e.g. amlodipine): the blood vessels to relax. Diuretics (water pills such as hydrochlorothiazide): they promote the excretion of salt and water, reducing blood volume decreases. Often a combination of two or more substances is prescribed, in order to achieve optimal blood pressure control. The goal is to keep the value of under 140/90 mmHg in elderly or high-risk patients, sometimes even lower. The of the biggest hurdles: the Compliance Despite its effectiveness, many of those Affected do not take your tablets regularly. Reasons for this are varied: Lack of disease awareness: hypertension is often a complaint. Many feel no difference whether you take the tablet or not and neglect the taking. Side effects: Dry cough (ACE‑inhibitors), dizziness, fatigue, or sexual dysfunction can affect the quality of life and cause patients to stop taking the medication. The complexity of the therapy: If multiple tablets are to be taken at different times, the daily Routine more difficult. Therapy is more than a pill Medications alone are often not enough. A healthy lifestyle is equally important: Movement (at least 30 minutes a day) Reduced salt consumption (less than 5 g per day) A balanced diet with plenty of fruits, vegetables and fiber Avoiding Smoking and excessive alcohol consumption Stress management and adequate sleep Conclusion Tablets used to treat high blood pressure are an important tool to prevent life-threatening sequelae. However, their effectiveness depends on the willingness of patients, long-term and regularly take. Open communication with the doctor, the balance between Benefit and risk, as well as the support by the family and the community can help in this crucial. High blood pressure can be checked and that the life can be significantly extended.

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NSAIDs in cardiovascular diseases. Diagnosis of cardiovascular diseases recommendations.

Edema in cardiovascular diseases: more quality of life to win You feel Edema — those unpleasant swelling of the legs, feet, or hands in your everyday life limited? In the case of cardiovascular diseases, Edema occur and can affect your well-being significantly. Our modern concept of treatment will help you relieve the symptoms effectively and to improve their quality of life. We offer: Individual diagnostics: conduct a thorough investigation to clarify the exact cause of your Edema. Personalized treatment: Tailor-made treatment plans in consultation with your cardiologist. Effective resolutions of corrugation: Innovative methods for the reduction of Edema and pain relief. Long-term support: Periodic checks and adjustment of therapy for sustainable success. You can rely on our experienced Team of cardiologists and physiotherapists. Together we will find the optimal way in order to feel lighter and more free. Make an appointment easily online or call us under +49 XXX XXXXXXX. Back to more freedom of movement — we will accompany you on this path!